国际精神病学杂志 ; 2025年 52卷 3期 ; 2025, 52(3): 772-775
李婷，
单位：聊城市人民医院
目的：探究奥卡西平联合喹硫平治疗对双相情感障碍躁狂发作患者临床症状及认知功能的影响。方法：回顾性分析2021年1月-2024年1月期间在我院就诊的双相情感障碍躁狂发作患者临床资料，按照治疗方法不同分为对照组（予以喹硫平治疗）和观察组（予以奥卡西平联合喹硫平治疗），采用1∶1最邻近匹配法进行倾向性评分匹配，最终每组各45例。比较治疗前和治疗1个月后两组患者的临床症状[临床总体印象疾病严重度量表-双相障碍版（clinical global impression severity scale-bipolar disorder version，CGI-BP）]、躁狂发作程度[躁狂量表（Bech-Rafaelsen Mania Rating Scale，BRMS）]、神经内分泌功能指标[血清甲状腺激素（thyroid hormone，TH）、皮质醇（cortisol，Cor）、促甲状腺激素（thyroid stimulating hormone，TSH）、促肾上腺皮质激素（adrenocorticotropic hormone，ACTH）]和认知功能[认知功能相关连线测试量表（cognitive function related trail making test，TMT）]，以及记录治疗期间两组患者不良反应发生情况。结果：治疗1个月后，两组患者的CGI-BP评分、BRMS评分、TH、Cor、ACTH、TMT量表时间较治疗前显著下降，且观察组低于对照组（P<0.05）；两组患者的TSH较治疗前显著提高，且观察组高于对照组（P<0.05）。在治疗期间，观察组的不良反应发生率显著高于对照组（P<0.05）。结论：奥卡西平联合喹硫平治疗能够有效缓解双相情感障碍躁狂发作患者症状，降低患者躁狂发作程度，改善神经内分泌功能和认知功能，具有较好的安全性。
关键词： 双相情感障碍；躁狂发作；奥卡西平；喹硫平；临床症状；认知功能
To explore the influence of oxcarbazepine combined with quetiapine on clinical symptoms and cognitive function in patients with bipolar disorder (BPD) complicated with manic episode. Methods: The clinical data of patients with BPD and manic episode in the hospital were retrospectively analyzed from January 2021 to January 2024. According to different treatment methods, they were divided into control group (quetiapine) and observation group (oxcarbazepine combined with quetiapine). The propensity score matching was performed by 1:1 nearest neighbor matching method. Finally, 45 cases were obtained in each group. The clinical symptoms [clinical global impression severity scale-bipolar disorder version (CGI-BP], manic episode degree [Bech-Rafaelsen Mania Rating Scale (BRMS)], neuroendocrine function indicators [serum thyroid hormone (TH), cortisol (Cor), thyroid stimulating hormone (TSH), adrenocorticotropic hormone (ACTH)] and cognitive function [ cognitive function related trail making test (TMT)] were compared between groups before treatment and after 1 month of treatment, and the adverse reactions in the two groups during treatment were recorded. Results: After 1 month of treatment, the CGI-BP score, BRMS score, TH, Cor, ACTH and TMT scale time in the two groups were significantly reduced than those before treatment, and the indicators in observation group were lower than those in control group (P<0.05). The TSH in both groups was significantly enhanced than that before treatment, and the observation group had higher TSH (P<0.05). During treatment, the incidence rates of adverse reactions in observation group were significantly higher than those in control group (P<0.05). Conclusion : Oxcarbazepine combined with quetiapine can effectively alleviate the symptoms of patients with BPD and manic episode, reduce the degree of manic episode, and improve the neuroendocrine function and cognitive function, and it has good safety.
Key words: Bidirectional disorder; Manic episode; Oxcarbazepine; Quetiapine; Clinical symptoms; Cognitive function
ISSN：1673-2952
CN：43-1457/R
主管单位：中华人民共和国教育部
主办单位：中南大学
刊期：双月刊
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