ABSTRACT

【Abstract】 Objective To investigate the clinical application of cognitive behavioral therapy for insomnia (CBT-I) combined with sertraline in treating patients with depression comorbid with anxiety and insomnia. 
Methods A total of 80 patients with depression comorbid with anxiety and insomnia treated in our hospital from January 2020 to December 2022 were selected and randomly assigned to either the observation group (40 cases) or the control group (40 cases) using a random number table. The control group received oral sertraline tablets, while the observation group received CBT-I in addition to the control group's treatment. The therapeutic efficacy, anxiety and depression levels, and sleep quality were compared between the two groups. 
Results A significantly higher overall response rate was observed in the observation group compared to the control group (P < 0.05). Following the intervention, both groups showed reductions in HAMD and HAMA scores, with the observation group demonstrating significantly greater reductions than the control group (P < 0.05). Both groups demonstrated a reduction in Pittsburgh Sleep Quality Index (PSQI) scores following the intervention, with a more pronounced decrease observed in the intervention group compared to the control(P < 0.05).
Conclusion   The combination of CBT-I and sertraline proves to be clinically effective in treating patients with comorbid depression, anxiety, and insomnia. It can alleviate symptoms of anxiety and depression and improve sleep quality.

Key words: 【Key words】 Depression; Anxiety; Insomnia; Cognitive Behavioral Therapy for Insomnia; Sertraline