ABSTRACT

[Abstract]Objective To examine the variations in serum inflammatory markers among children with recurrent asthma and their interconnections with sleep quality and negative emotional states.
Methods During the study period from January 2022 to January 2025, 95 children diagnosed with recurrent asthma were selected for the observation group. The control group was drawn from 80 healthy children undergoing physical examinations during the same period. All subjects underwent evaluation for inflammatory markers [C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α)]. To assess sleep patterns and emotional status, the Children's Sleep Habits Questionnaire (CSHQ), the Screen for Child Anxiety Related Emotional Disorders (SCARED), and the Children's Depression Inventory (CDI) were employed. A comparative analysis of all variables was undertaken between the two groups. Pearson's correlation coefficient was utilised to ascertain the relationship between serum inflammatory levels and sleep quality as well as negative emotion scores in children with asthma.
Results Relative to the control group, significantly higher concentrations of CRP, IL-6, and TNF-α were observed in the asthma group (P<0.05). Similarly, their scores on the CSHQ, SCARED, and CDI scales were also significantly greater (P<0.05). Subsequent analysis demonstrated that in children with asthma, serum levels of these inflammatory factors were positively correlated with the obtained sleep and negative emotion scores (P<0.05).
Conclusion   Children with recurrent asthma exhibit elevated serum inflammatory levels, reduced sleep quality, and increased anxiety and depression. Furthermore, inflammatory factors are significantly correlated with both sleep quality and negative emotions.

Key words: [Keywords]Bronchial asthma; Children; Inflammatory factors; Sleep quality; Anxiety; Depression; Correlation analysis